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ORIGINAL ARTICLE
Year : 2020  |  Volume : 17  |  Issue : 1  |  Page : 25-30

Evaluation of the effect of β-tricalcium phosphate nanoparticles on bone defect healing in diabetic rats


Department of Oral Biology, Faculty of Dental Medicine, Al-Azhar University (Males), Cairo, Egypt

Correspondence Address:
Galal A. Nasr
Department of Oral Biology, Faculty of Dental Medicine, Al-Azhar University (Males), Cairo, Kafr Elzayat, Elghrbia 31611
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tdj.tdj_37_19

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Aim The aim of this study was to evaluate histologically the bone defect's regeneration after application of β-tricalcium phosphate nanoparticles (Nβ-TCP) intibial bony defects of diabetic rats. Materials and methods Sixteen adult male albino rats were used and their weight was almost 250 g. The animals were grouped into two equal groups: group 1 (control diabetic) which had not receive the graft; group 2 (experimental diabetic) which had received the graft material (Nβ-TCP). Specimens were harvested on days 7 and 28 after surgical procedures, prepared, stained with hematoxylin and eosin, and examined histologically. Results The histological examination demonstrated obvious retardation in granulation tissue formation, organization and bone formation in the control diabetic group 1 than group 2 along the different intervals of this study. This retardation in the healing of diabetic contro1group was due to the effect of diabetes as it reduced cellular proliferation in early callus, collagen synthesis content, osteoblastic activity and reduced bone mineralization. Moreover, there was great acceleration in granulation tissue formation, organization and bone formation in experimental diabetic group 2 which received the graft material. Conclusion Nβ-TCP has been shown to have a good biocompatibility and osteoconductivity and can be used to enhance bone healing specially in retarded conditions as in diabetes mellitus.


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