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ORIGINAL ARTICLE
Year : 2018  |  Volume : 15  |  Issue : 2  |  Page : 99-104

An analysis of Bcl-2 and Bax markers expression in polymorphous low-grade adenocarcinoma and epithelial–myoepithelial carcinoma of salivary gland


1 Department of Oral Pathology, Faculty of Dentistry, Al-Azhar University, Cairo, Egypt
2 Department of Oral Biology, Faculty of Dentistry, Al-Azhar University, Cairo, Egypt
3 Department of Oral Medicine, Faculty of Dentistry, Taif University, Taif, Saudi Arabia

Correspondence Address:
Mohamed A Mohamed
Department of Oral Pathology, Faculty of Dentistry, Al.Azhar University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tdj.tdj_57_17

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Aim To study the evaluation of the expression of Bcl-2 and Bax markers in polymorphous low-grade adenocarcinoma (PLGA) and epithelial–myoepithelial carcinoma. Materials and Methods Hematoxylin and eosin and streptavidin–biotin immunoperoxidase staining techniques was used to detect the expression of Bcl-2 and Bax protein in five cases of PLGA and five cases of epithelial–myoepithelial carcinoma. Evaluation of immunostaining was done by image analysis computer system. Results Showed that there was a statistically significant difference (P < 0.001) in means of Bcl-2 and Bax expression between PLGA and epithelial–myoepithelial carcinoma. Conclusion The expression of Bcl-2 and Bax could be used as an effective biomarker to predict aggressive biologic behavior of PLGA and epithelial–myoepithelial carcinoma.


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