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Year : 2017  |  Volume : 14  |  Issue : 2  |  Page : 62-67

Role of CD44 and cortactin in metastasis of oral squamous cell carcinoma

1 Department of Oral Pathology, Faculty of Dentistry, Tanta University, Tanta, Egypt
2 Department of Pathology, Tanta Cancer Center, Tanta, Egypt

Correspondence Address:
Yomna S Abd El-Aziz
Department of Oral Pathology, Faculty of Dentistry, Tanta University, Tanta
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tdj.tdj_59_16

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Context: Oral squamous cell carcinoma (OSCC) is the most common form of head and neck cancer, and over the last decade its incidence has increased by 50%. The tendency of OSCC for local and regional metastasis is high and this is thought to be the greatest contributor to the morbidity and mortality associated with OSCC. Aim: The aim of this study was directed to evaluate the role of both cluster of differentiation 44 (CD44) and cortactin (CTTN) in lymph node (LN) metastasis of OSCC. Materials and methods: The study groups comprised blocks of OSCC with LN metastasis (n = 20) and blocks of OSCC without LN metastasis (n = 20). The blocks were prepared for immunohistochemical staining for CD44 and CTTN. Results: The result of this study revealed significant correlation between expression of both CD44 and CTTN and LN metastasis. Conclusion: From the present study, it can be concluded that assessment of CD44 and CTTN in OSCC represent an important tool for prediction of risk of metastasis for each case and the significant correlation between CD44 and CTTN could provide insights of their critical role in metastasis.

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